Forskning og kliniske studier
Ud over at bidrage til den almen hjerneforskning har HAPPYneurons videnskabelige team i samarbejde med anerkendte forskningsinstitutioner undersøgt de kognitive øvelsers effekt i forhold til forskellige kliniske tilstande. Ydermere har uafhængige forskere anvendt øvelserne i forskellige studier. Forskningen tyder på, at programmerne er effektive over for de kognitive dysfunktioner, som kan optræde i forbindelse med flere forskellige tilstande og lidelser. Nedenfor ses en oversigt over forskningsprojekter.
Studier omhandlende:
Undersøgelse
2016-2018: Translational Neuroscience Optimization of GlyT1 Inhibitor
Størrelse
80 forsøgspersoner
Forskningsinstitution
Yale University
Ansvarlig
John H. Krystal, M.D.
Status
I gang
Undersøgelse
2016-2017: Exploring cognitive training as a non-pharmaceutical therapeutic intervention for people with Huntington's disease
Størrelse
8 forsøgspersoner
Forskningsinstitution
Cardiff University in the Cardiff Huntington’s Disease Research Centre
Ansvarlig
Emma Yhnell, Pr Anne Rosser
Status
I gang
Undersøgelse
2016-2017: Neural bases of intrinsic motivation for learning in individuals at clinical high risk (CHR) for psychosis
Størrelse
12 forsøgspersoner
Forskningsinstitution
Olin Neuropsychiatry Research Center, the Institute of Living at Hartford Hospital
Ansvarlig
Jimmy Choi, Godfrey Pearlson, Michael Stevensn Joanna M. Fiszdon
Status
I gang
Undersøgelse
2016-2017: Cognitive training program on verbal memory in older women who are within a year of having undergone chemotherapy treatment for early‐stage breast cancer
Størrelse
40 forsøgspersoner
Forskningsinstitution
Rehabilitation Institute of Chicago, Northwestern Feinberg School of Medicine
Ansvarlig
Leora R. Cherney, Diane F. Morean, Alyx Kesselring
Status
I gang
Undersøgelse
2016: CBT for psychosis in combination with Cognitive Remediation
Størrelse
40 forsøgspersoner
Forskningsinstitution
Addictions & Mental Health Services - Kingston Frontenac Lennox & Addington
Ansvarlig
Dr. Farooq Naeem, Dr. Tariq Munshi, Dr. Muhammad Ayub, Dr. Rupy Johal
Status
I gang
Undersøgelse
2016: Evaluation of cognitive tele-rehabilitation program for children with Attention Deficit Hyperactivity Disorder
Størrelse
100 forsøgspersoner
Forskningsinstitution
Bio functional Studies Institute - Universidad Complutense (Madrid)
Ansvarlig
Elimelech Duarte, Jesus Alvarado, Alejandra Koeneke
Status
I gang
Undersøgelse
2015-2018: Cognitive and Physical Training in Elderly: Behavioral and EEG study
Størrelse
120 forsøgspersoner
Forskningsinstitution
Laboratoire d'Etude des Mécanismes Cognitifs, Université Lumière Lyon 2, France
Ansvarlig
Clémence Joubert (Ph.D student) & Hanna Chainay, Ph.D.
Status
I gang
Undersøgelse
2015-2017: Evaluation of Dallas Metrocare's Enhanced Program for Early Psychosis (ePEP)
Størrelse
90 forsøgspersoner
Forskningsinstitution
UT Southwestern Medical Center
Ansvarlig
Carol North, Ana Stan, Debra Bushong, Draper Bushanan
Status
I gang
Undersøgelse
2015-2016: Measuring the effectiveness of Cognitive Remediation on Schizophrenia and Depression
Forskningsinstitution
National Center of Neurology and Psychiatry, Japan
Ansvarlig
Kazuyuki Nakagome, M.D., Ph.D.
Status
I gang
Undersøgelse
2014-2019: Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia.
Størrelse
75 forsøgspersoner
Forskningsinstitution
University of British Columbia
Ansvarlig
Todd Woodward, Ph.D.
Status
I gang
Undersøgelse
2014-2018: Manualized group cognitive-behavioral therapy for social anxiety in first episode psychosis: A randomized controlled trial
Størrelse
120 forsøgspersoner
Forskningsinstitution
Douglas Mental Health University Insitute, Montreal, QC & Department of Psychiatry, McGill University, Montréal QC
Ansvarlig
Dr Martin Lepage, Ashol K. Malla, Dr Philippe-Olivier Harvey, Dr. Christopher Bowie
Status
I gang
Undersøgelse
2014-2018: Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia.
Størrelse
75 forsøgspersoner
Forskningsinstitution
University of British Columbia
Ansvarlig
Todd Woodward, Mahesh Menon, Devon Andersen
Status
I gang
Undersøgelse
2014-2017: The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial
Størrelse
126 forsøgspersoner
Forskningsinstitution
Psychiatric Center Copenhagen, Denmark
Ansvarlig
Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft.
Status
I gang
Undersøgelse
2014-2016: Cognitive Training protocols in people with Chronic Pain
Størrelse
50 forsøgspersoner
Forskningsinstitution
School of Psychological Sciences, Monash University; and Caufiled Pain Management and Research Center, Caulfield Hospital
Ansvarlig
Dr. Melita Giummarra, Pr. Nellie Georgiou-Karistianis, Pr. Stephen Gibson, Katharine Baker
Status
I gang
Undersøgelse
2014-2016: Comparing interventions that have either been designed to target the positive symptoms (particularly delusions) or the cognitive symptoms (e.g., memory and language deficits) of Schizophrenia
Forskningsinstitution
School of Psychology, Flinders University, Adelaide, SA, Australia
Ansvarlig
Dr Ryan Balzan
Status
I gang
Undersøgelse
2014-2015: Preparing people marginalized by mental health issues for further education/ employment through Education
Størrelse
25 forsøgspersoner
Forskningsinstitution
George Brown College
Ansvarlig
Jaswant Kaur Bajwa, Alex Irwin
Status
I gang
Undersøgelse
2014: Increased activation in Broca's area after cognitive remediation in schizophrenia
Størrelse
16 forsøgspersoner
Forskningsinstitution
Lausanne Hospital, Switzerland
Ansvarlig
Pascal Vianin, Ph.D., Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey
Status
Afsluttet
Publikation
Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey. Increased activation in Broca's area after cognitive remediation in schizophrenia. Psychiatry Research: Neuroimaging, Volume 221. Issue 3, 30 March 2014, pp 204-209. Click Here to Get an Electronic Copy
Undersøgelse
2014: Remote Cognitive Remediation for Psychosis
Forskningsinstitution
Ansvarlig
Status
I gang
Undersøgelse
2014: Cognitive Remediation for Geriatric Schizophrenia
Forskningsinstitution
Ansvarlig
Status
I gang
Undersøgelse
2014: Short-term, Intensive Executive Functioning Training with an Active Placebo
Forskningsinstitution
Ansvarlig
Status
I gang
Undersøgelse
2014: Remote Cognitive Remediation for Acutely Hospitalized Depression
Forskningsinstitution
Ansvarlig
Status
I gang
Undersøgelse
2014: Cognitive training to improve language comprehension for seniors?
Størrelse
50 forsøgspersoner - under recruitment
Forskningsinstitution
Jean-Uhrmacher Institut für klinische HNO-Forschung, Klinik und Poliklinik für Neurologie der Uniklinik Köln, Lehrstuhl für Pädagogik und Didaktik hörgeschädigter Menschen
Ansvarlig
Dr. Magdalene Ortmann, Prof. Dr. Harmut Meister, Prof. Dr. Josef Kessler, Prof. Dr. Thomas Kaul
Status
I gang
Præsentation
Undersøgelse
2013-2016: Web-based cognitive training for breast cancer survivors
with cognitive complaints—a randomized controlled trial
Størrelse
157 forsøgspersoner
Forskningsinstitution
Unit for Psychooncology and Health Psychology, Department of Oncology, Aarhus University Hospital and Department of Psychology and Behavioural Science, Aarhus University, Denmark
Ansvarlig
MF Damholdt, M Mehlsen, MS O’Toole, RK Andreasen, AD Pedersen, R Zachariae.
Sponsoreret af
Research was supported by TrygFonden
Status
Afsluttet
Publikation
Undersøgelse
2013-2015: Efficacy of psychological treatments for schizophrenia
Forskningsinstitution
School of Psychology, Flinders University, Adelaide, SA, Australia
Ansvarlig
Dr Ryan Balzan
Status
I gang
Undersøgelse
2013-2015: Scanning Training Rehabilitation for Visual Field Loss after stroke at Home: The STaRFiSH Study
Forskningsinstitution
Glasgow Caledonian University
Ansvarlig
Christine Hazelton, Dr. Alex Pollock
Status
I gang
Undersøgelse
2013-2015: Effects and efficacy of specialized social cognitive therapy compared to cognitive remediation therapy in people with schizophrenia
Størrelse
30 til 40 forsøgspersoner
Forskningsinstitution
McGill University Psychiatry Department
Ansvarlig
Philippe-Olivier Harvey
Status
I gang
Undersøgelse
2013-2014: Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study
Størrelse
17 forsøgspersoner
Forskningsinstitution
University of British Columbia
Ansvarlig
Jennifer DiMauro
Status
Afsluttet
Publikation
Jennifer DiMauro, Marla Genova, David F. Tolin, Matthew M. Kurtz, Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study, Journal of Obsessive-Compulsive and Related Disorders, Available online 2 April 2014, ISSN 2211-3649.
Undersøgelse
2012-2015: Identifying neuropsychological subgroups in patients with bipolar disorder and evaluation of a cognitive remediation program
Størrelse
190 forsøgspersoner
Forskningsinstitution
Ansvarlig
Julia Volkert, Supervisor: Prof. Dr. Andreas Reif
Status
I gang
Undersøgelse
2012: Conditions for Maximizing Effects of 90 Days of Brain Training
Størrelse
350 forsøgspersoner
Forskningsinstitution
Status
Afsluttet
Undersøgelse
2011-2013: Neurocognitive Enhancement in a Vocational Services Program
Størrelse
60 forsøgspersoner
Forskningsinstitution
Ansvarlig
Status
I gang
Undersøgelse
2011-2013: Cognitive Remediation for Treatment Resistant Depression
Forskningsinstitution
Ansvarlig
Status
Afsluttet
Publikation
Bowie CR, Gupta M, Holshausen K, Jokic R, Best, M, Milev, R. Cognitive remediation for treatment resistant depression: Effects on cognition and functioning and the role of online homework. Journal of Nervous and Mental Disorders, 2013, 201, 680-685.
Undersøgelse
2011: Increased employability of the unemployed aged 50+ through cognitive training?
Størrelse
87 forsøgspersoner
Forskningsinstitution
Ansvarlig
B. Godde, C. M. G. Noack, C. Windisch & C. Voelcker-Rehage
Status
Afsluttet
Undersøgelse
2010-2011: Cognitive Remediation Early Episode vs. Chronic Outpatients with Schizophrenia
Størrelse
30 forsøgspersoner
Forskningsinstitution
Ansvarlig
Sponsoreret af
NARSAD
Status
Afsluttet
Præsentation
Poster at Cognitive Remediation Conference 2011, New York, June 2011
Publikation
Bowie CR, McGurk SM, Mausbach BT, Patterson TL, Harvey PD. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real world behavior. American Journal of Psychiatry, 2012, 1-9
Undersøgelse
2009-2011: Intensive Spatial Memory Training for older Adults
Størrelse
40 forsøgspersoner
Forskningsinstitution
Ansvarlig
Status
Afsluttet
Publikation
Pending
Undersøgelse
2009-2011: Neurocognitive Enhancement Therapy for Major Depressive Disorder
Størrelse
40 forsøgspersoner
Forskningsinstitution
Ansvarlig
Status
Afsluttet
Præsentation
Poster at Cognitive Remediation Conference 2011, New York, June 2011
Publikation
Pending
Undersøgelse
2009: Specificity and Generalizability of Cognitive Remediation and Functional Skills Training in Schizophrenia
Størrelse
83 forsøgspersoner
Forskningsinstitution
Ansvarlig
Sponsoreret af
NARSAD
Status
Afsluttet
Præsentation
Cognitive Remediation in Psychiatry Conference, New York, June 2010
Publikation
Pending
Undersøgelse
2008-2012: Cognitive rehabilitation for depressed patients
Størrelse
30 forsøgspersoner
Forskningsinstitution
French National Science Research Center
Paris 6 University at La Pitié-Salpêtriére Hospital
Paris 6 University at La Pitié-Salpêtriére Hospital
Ansvarlig
Diane Samama, Ouriel Grynszpan, Ph.D., Odile Komano, Fernando Perez Diaz, Julie Guertault, Franck Tarpin-Bernard, Ph.D., Pr. Roland Jouvent.
Status
Afsluttet
Præsentation
Poster at Cognitive Remediation Conference 2011, New York, June 2011
Poster at Cognitive Remediation Conference 2012, New York, June 2012
Poster at Cognitive Remediation Conference 2012, New York, June 2012
Publikation
Pending
Undersøgelse
2008-2011: Cognitive remediation effectiveness for schizophrenic patients
Størrelse
280 forsøgspersoner multi-site
Ansvarlig
Nicolas Franck, Institute for Cognitive Science, Lyon, France
Sponsoreret af
Funded by PHRC (French Government Funding Program for Clinical Research)
Status
Afsluttet
Præsentation
Poster at 9th World Congress of Biological Psychiatry, Paris, France, July 2009
Publikation
Franck, N. et al. (2013). Specific vs general cognitive remediation for schizophrenia: a multicentre randomised trial. Schizophrenia Research, 147(1), pp. 68-74. Click Here to Get an Electronic Copy
Undersøgelse
2008: Cognitive Training Improves Driving Skills
Størrelse
90 forsøgspersoner
Ansvarlig
Status
Afsluttet
Resultater
Subjects demonstrate an average of 14% improvement in key skills
Undersøgelse
2008: Benefits of Online Cognitive Training
Størrelse
217 forsøgspersoner
Ansvarlig
Bernard Croisile, M.D., Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D., Diana Miner, M.A., M.S., Gaël Allain, Ph.D.
Status
Afsluttet
Resultater
Subjects demonstrate +8.5% average improvement
Publikation
Pending
Undersøgelse
2007: Alzheimer's patients maintain cognitive skills and improve self confidence
Størrelse
47 forsøgspersoner
Ansvarlig
Dr. Foare, Sophia's Gardens, Alzheimer's disease clinic, Castelnau-le-Lez, France
Status
Afsluttet
Undersøgelse
2007: Online Cognitive Training Improves Cognitive Performance
Størrelse
85 forsøgspersoner
Ansvarlig
Bernard Croisile, M.D., Ph.D., Sandrine Bélier, Ph.D., Michel Noir, Ph.D., Franck Tarpin-Bernard, Ph.D., Gaël Allain, Ph.D.
Status
Afsluttet
Resultater
85 HAPPYneuron Users show +16% average improvement in 18 weeks
Undersøgelse
2007: Significant Brain Activity Improvement
Ansvarlig
Robert Bender III, M.D., D.Michael
Sponsoreret af
The Center for Disease Control (CDC)
Status
Afsluttet
Resultater
“Shows Significant Brain Activity Improvement. HAPPYneuron™ Games Key Component of Brain Wellness Program”
Undersøgelse
2006-2008: Rehabilitation software program for schizophrenia patients
Størrelse
28 forsøgspersoner
Forskningsinstitution
Lausanne Hospital, Switzerland
Ansvarlig
Sponsoreret af
CHUV (Centre Hospitalier Universitaire Vaudois)
Status
Afsluttet
Publikation
Vianin, P., Deppen, P., Croisile, B., Tarpin-Bernard, F., Sarrasin-Bruchez, P., Dukes, R., Grillon, M. Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia. The Journal of Cognitive Rehabilitation, NeuroScience Publishers, Volume 28. Fall 2010, pp 11-21, Click Here to Get an Electronic Copy
Undersøgelse
2006: Memory Stimulation. Which scientific benefits? Which exercises?
Størrelse
39 forsøgspersoner
Ansvarlig
Status
Afsluttet
Resultater
HAPPYneuron Users show +12% average improvement in 18 weeks
Publikation
Undersøgelse
2004-2006: MNESIS Project - Using the internet as a means of social integration and cognitive stimulation in a residential unit for elderlies
Forskningsinstitution
Lyon 2 University, Lyon INSA (ICTT), Medica-France
Ansvarlig
Michel C., Bobillier-Chaumon M.-E., Cohen-Montandreau V., Tarpin-Bernard F.
Sponsoreret af
French Ministry of Industry
Status
Afsluttet
Præsentation
Elderlies in residential home care units. Can ICT be considered as a social rebinding method? In Conférence EUTIC 2006
Publikation
Marc-Eric Bobillier Chaumon, Christine Michel, Franck Tarpin Bernard & Bernard Croisile , Behaviour & Information Technology (2013): Can ICT improve the quality of life of elderly adults living in residential home care units? From actual impacts to hidden artefacts, Behaviour & Information Technology, pp 1-17. Click Here to Get an Electronic Copy
Undersøgelse
2003-2006: The Importance of Memory and Concentration Skills for Schoolchildren
Størrelse
130 forsøgspersoner school children ages 10 and 11, over a 3 year time frame
Forskningsinstitution
City of Elancourt, France ; Association Initiatives Terrain, France ; Lille University, France
Ansvarlig
Neukirch A., Fenouillet F., Hildebrandt R.
Status
Afsluttet
Resultater
Better CMS score and various effects on recognition tasks.
Publikation
Pending
Undersøgelse
2001-2002: Transferability of Cognitive Training to every-day activities (AKA King 64)
Størrelse
117 forsøgspersoner children, 10 years old
Forskningsinstitution
EMC laboratory (Université Lyon II - CNRS), France
Ansvarlig
Status
Afsluttet
Resultater
Average of 40%+ improvements in various cognitive skills performance.
Publikation